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Ligation of CD8 leads to apoptosis of thymocytes that have not undergone positive selection
Thymocytes that are not positively selected are said to undergo “death by neglect.” We have found that ligation of CD8, either by antibodies or MHC class I molecules, induces apoptosis of CD4(+)CD8(+) double-positive (DP) thymocytes. The susceptibility of thymocytes to CD8-mediated apoptosis is deve...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC478585/ https://ncbi.nlm.nih.gov/pubmed/15232005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402079101 |
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