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Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8(+) T cells

Many studies have positioned Notch signaling at various critical junctions during T-cell development. There is, however, debate regarding the role of Notch in the CD4 versus CD8 lineage commitment. Because there are 4 Notch receptors and RBP-Jκ–independent Notch signaling has been reported, we decid...

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Detalhes bibliográficos
Main Authors: Maraver, Antonio, Tadokoro, Carlos E., Badura, Michelle L., Shen, Jie, Serrano, Manuel, Lafaille, Juan J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200904/
https://ncbi.nlm.nih.gov/pubmed/17626841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-01-070359
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