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The 70-kDa heat shock protein chaperone nucleotide-binding domain in solution unveiled as a molecular machine that can reorient its functional subdomains
The 70-kDa heat shock cognate (Hsc70) chaperone plays a crucial role in protein (re-)folding and triage in the mammalian cytosol. Here we study, by NMR, the 44-kDa nucleotide-binding domain (NBD) of this molecule, which allosterically regulates, by binding either ADP or ATP in a cleft between the tw...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2004
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC478562/ https://ncbi.nlm.nih.gov/pubmed/15232009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401313101 |
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