Germline mutations in BRCA1, BRCA2, CHEK2 and TP53 in patients at high-risk for HBOC: characterizing a Northeast Brazilian Population

Considering the importance of BRCA1, BRCA2, CHEK2 and TP53 in the development of hereditary early-onset breast and ovarian cancer and that the genetic susceptibility profile of the Northeast population from Brazil has never been analyzed, this study aimed to verify the frequency of mutations of clin...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Hum Genome Var
Main Authors: Felix, Gabriela ES, Abe-Sandes, Camila, Machado-Lopes, Taísa MB, Bomfim, Thaís F, Guindalini, Rodrigo Santa Cruz, Santos, Vanessa Catarine SAR, Meyer, Lorena, Oliveira, Polyanna C, Cláudio Neiva, João, Meyer, Roberto, Romeo, Maura, Betânia Toralles, Maria, Nascimento, Ivana, Abe-Sandes, Kiyoko
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785545/
https://ncbi.nlm.nih.gov/pubmed/27081505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/hgv.2014.12
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