Estrogen ameliorates microglial activation by inhibiting the Kir2.1 inward-rectifier K(+) channel

Microglial activation is implicated in the pathogenesis of Parkinson’s disease (PD). Although the etiology of PD remains unclear, age and male gender are known PD risk factors. By comparing microglia and dopaminergic (DA) neurons in the substantia nigra (SN) of male and female mice of different ages...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Wu, Shih-Ying, Chen, Yun-Wen, Tsai, Sheng-Feng, Wu, Sheng-Nan, Shih, Yao-Hsiang, Jiang-Shieh, Ya-Fen, Yang, Ting-Ting, Kuo, Yu-Min
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785403/
https://ncbi.nlm.nih.gov/pubmed/26960267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22864
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