Estrogen ameliorates microglial activation by inhibiting the Kir2.1 inward-rectifier K(+) channel

Microglial activation is implicated in the pathogenesis of Parkinson’s disease (PD). Although the etiology of PD remains unclear, age and male gender are known PD risk factors. By comparing microglia and dopaminergic (DA) neurons in the substantia nigra (SN) of male and female mice of different ages...

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Vydáno v:Sci Rep
Hlavní autoři: Wu, Shih-Ying, Chen, Yun-Wen, Tsai, Sheng-Feng, Wu, Sheng-Nan, Shih, Yao-Hsiang, Jiang-Shieh, Ya-Fen, Yang, Ting-Ting, Kuo, Yu-Min
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785403/
https://ncbi.nlm.nih.gov/pubmed/26960267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22864
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