Castration influences intestinal microflora and induces abdominal obesity in high-fat diet-fed mice

Late-onset hypogonadism (i.e. androgen deficiency) raises the risk for abdominal obesity in men. The mechanism for this obesity is unclear. Here, we demonstrated that hypogonadism after castration caused abdominal obesity in high-fat diet (HFD)-fed, but not in standard diet (SD)-fed, C57BL/6J mice....

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Veröffentlicht in:Sci Rep
Hauptverfasser: Harada, Naoki, Hanaoka, Ryo, Horiuchi, Hiroko, Kitakaze, Tomoya, Mitani, Takakazu, Inui, Hiroshi, Yamaji, Ryoichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785334/
https://ncbi.nlm.nih.gov/pubmed/26961573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23001
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