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Castration influences intestinal microflora and induces abdominal obesity in high-fat diet-fed mice

Late-onset hypogonadism (i.e. androgen deficiency) raises the risk for abdominal obesity in men. The mechanism for this obesity is unclear. Here, we demonstrated that hypogonadism after castration caused abdominal obesity in high-fat diet (HFD)-fed, but not in standard diet (SD)-fed, C57BL/6J mice....

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Harada, Naoki, Hanaoka, Ryo, Horiuchi, Hiroko, Kitakaze, Tomoya, Mitani, Takakazu, Inui, Hiroshi, Yamaji, Ryoichi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785334/
https://ncbi.nlm.nih.gov/pubmed/26961573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23001
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