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Pharmacodynamic Evaluation of the Neutralization of Endotoxin by PMX622 in Mice
Polymyxin B (PMB) binds to and neutralizes endotoxin, but its systemic clinical utility is limited by neuro- and nephrotoxicity. PMX622 is a covalent conjugate of PMB and Dextran-70 designed to retain the ability of PMB to neutralize endotoxin and to retain the favorable colloidal, pharmacokinetic,...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2004
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC478528/ https://ncbi.nlm.nih.gov/pubmed/15273110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.8.2987-2992.2004 |
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