Pharmacodynamic Evaluation of the Neutralization of Endotoxin by PMX622 in Mice

Polymyxin B (PMB) binds to and neutralizes endotoxin, but its systemic clinical utility is limited by neuro- and nephrotoxicity. PMX622 is a covalent conjugate of PMB and Dextran-70 designed to retain the ability of PMB to neutralize endotoxin and to retain the favorable colloidal, pharmacokinetic,...

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Bibliographic Details
Main Authors: Lake, Philip, DeLeo, Jeffrey, Cerasoli, Franklin, Logdberg, Lennart, Weetall, Marla, Handley, Dean
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Biologic Response Modifiers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC478528/
https://ncbi.nlm.nih.gov/pubmed/15273110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.8.2987-2992.2004
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