Pharmacodynamic Evaluation of the Neutralization of Endotoxin by PMX622 in Mice

Polymyxin B (PMB) binds to and neutralizes endotoxin, but its systemic clinical utility is limited by neuro- and nephrotoxicity. PMX622 is a covalent conjugate of PMB and Dextran-70 designed to retain the ability of PMB to neutralize endotoxin and to retain the favorable colloidal, pharmacokinetic,...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Lake, Philip, DeLeo, Jeffrey, Cerasoli, Franklin, Logdberg, Lennart, Weetall, Marla, Handley, Dean
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2004
Assuntos:
Biologic Response Modifiers
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC478528/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15273110/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.8.2987-2992.2004
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