Pharmacodynamic Evaluation of the Neutralization of Endotoxin by PMX622 in Mice

Polymyxin B (PMB) binds to and neutralizes endotoxin, but its systemic clinical utility is limited by neuro- and nephrotoxicity. PMX622 is a covalent conjugate of PMB and Dextran-70 designed to retain the ability of PMB to neutralize endotoxin and to retain the favorable colloidal, pharmacokinetic,...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Lake, Philip, DeLeo, Jeffrey, Cerasoli, Franklin, Logdberg, Lennart, Weetall, Marla, Handley, Dean
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2004
Fag:	Biologic Response Modifiers
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC478528/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15273110/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.8.2987-2992.2004
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