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Pharmacodynamic Evaluation of the Neutralization of Endotoxin by PMX622 in Mice
Polymyxin B (PMB) binds to and neutralizes endotoxin, but its systemic clinical utility is limited by neuro- and nephrotoxicity. PMX622 is a covalent conjugate of PMB and Dextran-70 designed to retain the ability of PMB to neutralize endotoxin and to retain the favorable colloidal, pharmacokinetic,...
Tallennettuna:
| Julkaisussa: | Antimicrob Agents Chemother |
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| Päätekijät: | , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Microbiology (ASM)
2004
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC478528/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15273110/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.8.2987-2992.2004 |
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