Estimation of Serum-Free 50-Percent Inhibitory Concentrations for Human Immunodeficiency Virus Protease Inhibitors Lopinavir and Ritonavir

Using measured free fraction and 50% inhibitory concentration (IC(50)) values for the human immunodeficiency virus protease inhibitors lopinavir (LPV) and ritonavir (RTV) in tissue culture media with various protein concentrations ranging from 5 to 50%, we estimated serum-free IC(50) values for each...

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Autors principals: Hickman, Dean, Vasavanonda, Sudthida, Nequist, George, Colletti, Lynn, Kati, Warren M., Bertz, Richard, Hsu, Ann, Kempf, Dale J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC478510/
https://ncbi.nlm.nih.gov/pubmed/15273100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.8.2911-2917.2004
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