Estimation of Serum-Free 50-Percent Inhibitory Concentrations for Human Immunodeficiency Virus Protease Inhibitors Lopinavir and Ritonavir

Using measured free fraction and 50% inhibitory concentration (IC(50)) values for the human immunodeficiency virus protease inhibitors lopinavir (LPV) and ritonavir (RTV) in tissue culture media with various protein concentrations ranging from 5 to 50%, we estimated serum-free IC(50) values for each...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Hickman, Dean, Vasavanonda, Sudthida, Nequist, George, Colletti, Lynn, Kati, Warren M., Bertz, Richard, Hsu, Ann, Kempf, Dale J.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2004
Schlagworte:	Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC478510/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15273100/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.8.2911-2917.2004
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