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DNMT3b modulates melanoma growth by controlling levels of mTORC2 component RICTOR

DNA methyltransferase DNMT3B is frequently overexpressed in tumor cells and plays important roles during the formation and progression of several cancer types. However, the specific signaling pathways controlled by DNMT3B in cancers, including melanoma, are poorly understood. Here, we report that DN...

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Publicado en:Cell Rep
Autores principales: Micevic, Goran, Muthusamy, Viswanathan, Damsky, William, Theodosakis, Nicholas, Liu, Xiaoni, Meeth, Katrina, Wingrove, Emily, Santhanakrishnan, Manjula, Bosenberg, Marcus
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785087/
https://ncbi.nlm.nih.gov/pubmed/26923591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.02.010
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