mTORC1 activation blocks Braf(V600E)-induced growth-arrest, but is insufficient for melanoma formation

Braf(V600E) induces benign, growth-arrested melanocytic nevus development, but also drives melanoma formation. Cdkn2a loss in Braf(V600E) melanocytes in mice results in rare progression to melanoma, but only after stable growth arrest as nevi. Immediate progression to melanoma is prevented by upregu...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Damsky, William, Micevic, Goran, Meeth, Katrina, Muthusamy, Viswanathan, Curley, David P., Santhankrishnan, Manjula, Erdelyi, Ildiko, Platt, James T., Huang, Laura, Theodosakis, Nicholas, Zaidi, M. Raza, Tighe, Scott, Davies, Michael A., Dankort, David, McMahon, Martin, Merlino, Glenn, Bardeesy, Nabeel, Bosenberg, Marcus
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295062/
https://ncbi.nlm.nih.gov/pubmed/25584893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.11.014
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