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UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 Mouse Melanoma Model

Human melanomas exhibit relatively high somatic mutation burden compared to other malignancies. These somatic mutations may produce neoantigens that are recognized by the immune system, leading to an anti-tumor response. By irradiating a parental mouse melanoma cell line carrying three driver mutati...

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Bibliografske podrobnosti
izdano v:Pigment Cell Melanoma Res
Main Authors: Wang, Jake, Perry, Curtis Jamison, Meeth, Katrina, Thakral, Durga, Damsky, William, Micevic, Goran, Kaech, Susan, Blenman, Kim, Bosenberg, Marcus
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820096/
https://ncbi.nlm.nih.gov/pubmed/28379630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12591
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