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Shared Epitope Antagonistic Ligands - A New Therapeutic Strategy in Mice with Erosive Arthritis
OBJECTIVE: The mechanisms underlying bone damage in rheumatoid arthritis (RA) are incompletely understood. We recently identified the shared epitope (SE), an HLA-DRB1-coded 5 amino acid sequence motif carried by the majority of RA patients, as a signal transduction ligand that interacts with cell su...
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| Publicado no: | Arthritis Rheumatol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4784479/ https://ncbi.nlm.nih.gov/pubmed/25892196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39158 |
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