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New cancer targets emerging from studies of the Von Hippel-Lindau tumor suppressor protein
Inactivation of the von Hippel-Lindau tumor suppressor protein (pVHL) causes the most common form of kidney cancer. pVHL is part of a complex that polyubiquitinates the alpha subunit of the heterodimeric transcription factor HIF. In the presence of oxygen HIFa is prolyl hydroxylated by EglN1 (also c...
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| 發表在: | Ann N Y Acad Sci |
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| 主要作者: | |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4784475/ https://ncbi.nlm.nih.gov/pubmed/20973793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1749-6632.2010.05781.x |
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