Physiological, pharmacokinetic and liver metabolism comparisons between 3-, 6-, 12- and 18-month-old male Sprague Dawley rats under ketamine-xylazine anesthesia

The main objective of this study was to compare the physiological changes (withdrawal and corneal reflexes, respiratory and cardiac frequency, blood oxygen saturation, and rectal temperature) following intraperitoneal administration of ketamine (80 mg/kg) and xylazine (10 mg/kg) to 3-, 6-, 12- and 1...

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Bibliografske podrobnosti
izdano v:Exp Anim
Main Authors: Giroux, Marie-Chantal, Santamaria, Raphael, Hélie, Pierre, Burns, Patrick, Beaudry, Francis, Vachon, Pascal
Format: Artigo
Jezik:Inglês
Izdano: Japanese Association for Laboratory Animal Science 2015
Teme:
Original
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783652/
https://ncbi.nlm.nih.gov/pubmed/26489361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1538/expanim.15-0039
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