Pharmacokinetics of Ketamine and Xylazine in Young and Old Sprague–Dawley Rats

To compare the pharmacokinetics of coadministered intraperitoneal ketamine and xylazine in young (8 to 10 wk; n = 6) and old rats (2 to 2.4 y; n = 6), blood samples obtained at 15 and 30 min and 1, 2, and 4 h after drug administration were analyzed by HPLC–tandem mass spectrometry. In both groups, t...

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Dettagli Bibliografici
Autori principali: Veilleux-Lemieux, Daphnée, Castel, Aude, Carrier, Denise, Beaudry, Francis, Vachon, Pascal
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for Laboratory Animal Science 2013
Soggetti:
Anesthesia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784662/
https://ncbi.nlm.nih.gov/pubmed/24041212
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