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Physiological, pharmacokinetic and liver metabolism comparisons between 3-, 6-, 12- and 18-month-old male Sprague Dawley rats under ketamine-xylazine anesthesia

The main objective of this study was to compare the physiological changes (withdrawal and corneal reflexes, respiratory and cardiac frequency, blood oxygen saturation, and rectal temperature) following intraperitoneal administration of ketamine (80 mg/kg) and xylazine (10 mg/kg) to 3-, 6-, 12- and 1...

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Détails bibliographiques
Publié dans:Exp Anim
Auteurs principaux: Giroux, Marie-Chantal, Santamaria, Raphael, Hélie, Pierre, Burns, Patrick, Beaudry, Francis, Vachon, Pascal
Format: Artigo
Langue:Inglês
Publié: Japanese Association for Laboratory Animal Science 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783652/
https://ncbi.nlm.nih.gov/pubmed/26489361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1538/expanim.15-0039
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