CD19 controls TLR9 responses in human B cells

BACKGROUND: CD19 is a B-cell specific molecule that serves as a major co-stimulatory molecule for amplifying B cell receptor (BCR) responses. Bi-allelic CD19 gene mutations cause common variable immunodeficiency (CVID) in humans. BCR and TLR9 induced B-cell responses are impaired in most CVID patien...

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Détails bibliographiques
Publié dans:J Allergy Clin Immunol
Auteurs principaux: Morbach, Henner, Schickel, Jean-Nicolas, Cunningham-Rundles, Charlotte, Conley, Mary Ellen, Reisli, Ismail, Franco, Jose Luis, Meffre, Eric
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783287/
https://ncbi.nlm.nih.gov/pubmed/26478008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.08.040
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