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Drug Repositioning for Cancer Therapy Based on Large-Scale Drug-Induced Transcriptional Signatures
An in silico chemical genomics approach is developed to predict drug repositioning (DR) candidates for three types of cancer: glioblastoma, lung cancer, and breast cancer. It is based on a recent large-scale dataset of ~20,000 drug-induced expression profiles in multiple cancer cell lines, which pro...
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| Publicado no: | PLoS One |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4783079/ https://ncbi.nlm.nih.gov/pubmed/26954019 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150460 |
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