Inhibition of CXCR4 by LY2624587, a Fully Humanized Anti-CXCR4 Antibody Induces Apoptosis of Hematologic Malignancies

SDF-1 and CXCR4 are a chemokine and chemokine receptor pair playing critical roles in tumorigenesis. Overexpression of CXCR4 is a hallmark of many hematological malignancies including acute myeloid leukemia, chronic lymphocytic leukemia and non-Hodgkin’s lymphoma, and generally correlates with a poo...

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Vydáno v:PLoS One
Hlavní autoři: Peng, Sheng-Bin, Zhang, Xiaoyi, Paul, Donald, Kays, Lisa M., Ye, Ming, Vaillancourt, Peter, Dowless, Michele, Stancato, Louis F., Stewart, Julie, Uhlik, Mark T., Long, Haiyan, Chu, Shaoyou, Obungu, Victor H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782998/
https://ncbi.nlm.nih.gov/pubmed/26954567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150585
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