Inhibition of CXCR4 by LY2624587, a Fully Humanized Anti-CXCR4 Antibody Induces Apoptosis of Hematologic Malignancies

SDF-1 and CXCR4 are a chemokine and chemokine receptor pair playing critical roles in tumorigenesis. Overexpression of CXCR4 is a hallmark of many hematological malignancies including acute myeloid leukemia, chronic lymphocytic leukemia and non-Hodgkin’s lymphoma, and generally correlates with a poo...

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發表在:PLoS One
Main Authors: Peng, Sheng-Bin, Zhang, Xiaoyi, Paul, Donald, Kays, Lisa M., Ye, Ming, Vaillancourt, Peter, Dowless, Michele, Stancato, Louis F., Stewart, Julie, Uhlik, Mark T., Long, Haiyan, Chu, Shaoyou, Obungu, Victor H.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782998/
https://ncbi.nlm.nih.gov/pubmed/26954567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150585
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