Reporter gene imaging identifies intratumoral infection voids as a critical barrier to systemic oncolytic virus efficacy

Systemically administered oncolytic viruses have the ability to cause tumor destruction through the expansion and coalescence of intratumoral infectious centers. Efficacy is therefore dependent upon both the density and intratumoral distribution of virus-infected cells achieved after initial virus i...

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Veröffentlicht in:Mol Ther Oncolytics
Hauptverfasser: Miller, Amber, Suksanpaisan, Lukkana, Naik, Shruthi, Nace, Rebecca, Federspiel, Mark, Peng, Kah Whye, Russell, Stephen J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782940/
https://ncbi.nlm.nih.gov/pubmed/27119095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mto.2014.5
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