Safety Studies in Tumor and Non-Tumor-Bearing Mice in Support of Clinical Trials Using Oncolytic VSV-IFNβ-NIS

Oncolytic VSV-IFNβ-NIS is selectively destructive to tumors. Here, we present the IND enabling preclinical rodent studies in support of clinical testing of vesicular stomatitis virus (VSV) as a systemic therapy. Efficacy studies showed dose-dependent tumor regression in C57BL/KaLwRij mice bearing sy...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther Clin Dev
Main Authors: Zhang, Lianwen, Steele, Michael B., Jenks, Nathan, Grell, Jacquelyn, Suksanpaisan, Lukkana, Naik, Shruthi, Federspiel, Mark J., Lacy, Martha Q., Russell, Stephen J., Peng, Kah-Whye
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076487/
https://ncbi.nlm.nih.gov/pubmed/27532609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/humc.2016.061
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