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Meningeal myeloma deposits adversely impact the therapeutic index of an oncolytic VSV
Vesicular Stomatitis Virus (VSV) is neuropathogenic in rodents but can be attenuated 50-fold by engineering the mouse interferon-beta (IFN-β) gene into its genome. Intravenously administered VSVs encoding IFN-β have potent activity against subcutaneous tumors in the 5TGM1 mouse myeloma model, withou...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3855306/ https://ncbi.nlm.nih.gov/pubmed/24176894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2013.63 |
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