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Visualization of APP and BACE-1 approximation in neurons: new insights into the amyloidogenic pathway
Cleavage of APP (amyloid precursor protein) by BACE-1 (β-site APP cleaving enzyme-1) is the rate-limiting step in amyloid-beta (Aβ) production and a neuropathologic hallmark of Alzheimer's disease (AD); thus physical approximation of this substrate-enzyme pair is a critical event with broad bio...
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| Publicado no: | Nat Neurosci |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4782935/ https://ncbi.nlm.nih.gov/pubmed/26642089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4188 |
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