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Visualization of APP and BACE-1 approximation in neurons: new insights into the amyloidogenic pathway
Cleavage of APP (amyloid precursor protein) by BACE-1 (β-site APP cleaving enzyme-1) is the rate-limiting step in amyloid-beta (Aβ) production and a neuropathologic hallmark of Alzheimer's disease (AD); thus physical approximation of this substrate-enzyme pair is a critical event with broad bio...
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| Опубликовано в: : | Nat Neurosci |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4782935/ https://ncbi.nlm.nih.gov/pubmed/26642089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4188 |
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