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Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway
The convergence of APP (substrate) and BACE-1 (enzyme) is a rate-limiting, obligatory event triggering the amyloidogenic pathway – a key step in Alzheimer’s disease (AD) pathology. However, as both APP/BACE-1 are highly expressed in brain, mechanisms precluding their unabated convergence are unclear...
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| Główni autorzy: | , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2013
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3741682/ https://ncbi.nlm.nih.gov/pubmed/23931995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.05.035 |
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