Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway

The convergence of APP (substrate) and BACE-1 (enzyme) is a rate-limiting, obligatory event triggering the amyloidogenic pathway – a key step in Alzheimer’s disease (AD) pathology. However, as both APP/BACE-1 are highly expressed in brain, mechanisms precluding their unabated convergence are unclear...

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Bibliographic Details
Main Authors: Das, Utpal, Scott, David, Ganguly, Archan, Koo, Edward H., Tang, Yong, Roy, Subhojit
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741682/
https://ncbi.nlm.nih.gov/pubmed/23931995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.05.035
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