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Novel Curcumin Analogs to Overcome EGFR-TKI Lung Adenocarcinoma Drug Resistance and Reduce EGFR-TKI-induced GI Adverse Effects
Curcumin (1) down-regulates the expression as well as phosphorylation of epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells expressing gefitinib-resistant EGFR. Thirty-seven newly synthesized curcumin analogues including dimethoxycurcumin (2, DMC) were evaluated for their effects o...
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| Publicat a: | Bioorg Med Chem |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4782611/ https://ncbi.nlm.nih.gov/pubmed/25753330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.02.003 |
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