Novel Curcumin Analogs to Overcome EGFR-TKI Lung Adenocarcinoma Drug Resistance and Reduce EGFR-TKI-induced GI Adverse Effects

Curcumin (1) down-regulates the expression as well as phosphorylation of epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells expressing gefitinib-resistant EGFR. Thirty-seven newly synthesized curcumin analogues including dimethoxycurcumin (2, DMC) were evaluated for their effects o...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Wada, Koji, Lee, Jen-Yi, Hung, Hsin-Yi, Shi, Qian, Lin, Li, Zhao, Yu, Goto, Masuo, Yang, Pan-Chyr, Kuo, Sheng-Chu, Chen, Hui-Wen, Lee, Kuo-Hsiung
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782611/
https://ncbi.nlm.nih.gov/pubmed/25753330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.02.003
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