Antitumor agents 290. () Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgens

In our continuing study of curcumin analogs as potential anti-prostate cancer drug candidates, 15 new curcumin analogs were designed, synthesized and evaluated for cytotoxicity against two human prostate cancer cell lines, androgen-dependent LNCaP and androgen-independent PC-3. Twelve analogs (5-12,...

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Detalhes bibliográficos
Main Authors: Shi, Qian, Wada, Koji, Ohkoshi, Emika, Lin, Li, Huang, Rong, Morris-Natschke, Susan L., Goto, Masuo, Lee, Kuo-Hsiung
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376200/
https://ncbi.nlm.nih.gov/pubmed/22672984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.05.011
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