A murine model of K-ras and β-catenin induced renal tumors express high levels of E2F1 and resemble human Wilms Tumor

BACKGROUND: Wilms tumor (WT) is the most common renal neoplasm of childhood. We previously showed that restricted activation of the WNT/β-catenin pathway in renal epithelium late in kidney development is sufficient to induce small primitive neoplasms with features of epithelial WT. Metastatic diseas...

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Gepubliceerd in:J Urol
Hoofdauteurs: Yi, Yajun, Polosukhina, Dina, Love, Harold D., Hembd, Austin, Pickup, Michael, Moses, Harold L., Lovvorn, Harold N., Zent, Roy, Clark, Peter E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782590/
https://ncbi.nlm.nih.gov/pubmed/25934441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.juro.2015.04.090
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