β-Catenin and K-RAS Synergize to Form Primitive Renal Epithelial Tumors with Features of Epithelial Wilms' Tumors

Wilms' tumor (WT) is the most common childhood renal cancer. Although mutations in known tumor-associated genes (WT1, WTX, and CATNB) occur only in a third of tumors, many tumors show evidence of activated β-catenin–dependent Wnt signaling, but the molecular mechanism by which this occurs is un...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Clark, Peter E., Polosukhina, Dina, Love, Harold, Correa, Hernan, Coffin, Cheryl, Perlman, Elizabeth J., de Caestecker, Mark, Moses, Harold L., Zent, Roy
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2011
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260797/
https://ncbi.nlm.nih.gov/pubmed/21983638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.08.006
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky