β-Catenin and K-RAS Synergize to Form Primitive Renal Epithelial Tumors with Features of Epithelial Wilms' Tumors

Wilms' tumor (WT) is the most common childhood renal cancer. Although mutations in known tumor-associated genes (WT1, WTX, and CATNB) occur only in a third of tumors, many tumors show evidence of activated β-catenin–dependent Wnt signaling, but the molecular mechanism by which this occurs is un...

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Detalhes bibliográficos
Main Authors: Clark, Peter E., Polosukhina, Dina, Love, Harold, Correa, Hernan, Coffin, Cheryl, Perlman, Elizabeth J., de Caestecker, Mark, Moses, Harold L., Zent, Roy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260797/
https://ncbi.nlm.nih.gov/pubmed/21983638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.08.006
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