UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous group of hematological tumors composed of distinct subtypes that vary in their genetic abnormalities, gene expression signatures, and prognoses. However, it remains unclear whether T-ALL subtypes differ at the functional level, and, as s...

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Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Benyoucef, Aissa, Palii, Carmen G., Wang, Chaochen, Porter, Christopher J., Chu, Alphonse, Dai, Fengtao, Tremblay, Véronique, Rakopoulos, Patricia, Singh, Kulwant, Huang, Suming, Pflumio, Francoise, Hébert, Josée, Couture, Jean-Francois, Perkins, Theodore J., Ge, Kai, Dilworth, F. Jeffrey, Brand, Marjorie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782046/
https://ncbi.nlm.nih.gov/pubmed/26944678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.276790.115
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