Assessment of thiopurine methyltransferase activity in patients prescribed azathioprine or other thiopurine-based drugs.

OBJECTIVES: To examine whether pretreatment determination of thiopurine methyltransferase (TPMT) enzymatic activity (phenotyping) or TPMT genotype, to guide thiopurine therapy in chronic autoimmune disease patients, reduces treatment harms. Other objectives included assessing: preanalytic, analytic,...

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Dades bibliogràfiques
Publicat a:Evid Rep Technol Assess (Full Rep)
Autors principals: Booth, Ronald A, Ansari, Mohammed T, Tricco, Andrea C, Loit, Evelin, Weeks, Laura, Doucette, Steve, Skidmore, Becky, Hoch, Jeffrey S, Tsouros, Sophia, Sears, Margaret, Sy, Richmond, Karsh, Jacob, Mani, Suja, Galipeau, James, Yurkiewich, Alexander, Daniel, Raymond, Tsertsvadze, Alexander, Yazdi, Fatemeh
Format: Artigo
Idioma:Inglês
Publicat: United States. Agency for Healthcare Research and Quality 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4781432/
https://ncbi.nlm.nih.gov/pubmed/23126559
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