Assessment of thiopurine methyltransferase activity in patients prescribed azathioprine or other thiopurine-based drugs.

OBJECTIVES: To examine whether pretreatment determination of thiopurine methyltransferase (TPMT) enzymatic activity (phenotyping) or TPMT genotype, to guide thiopurine therapy in chronic autoimmune disease patients, reduces treatment harms. Other objectives included assessing: preanalytic, analytic,...

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Vydáno v:Evid Rep Technol Assess (Full Rep)
Hlavní autoři: Booth, Ronald A, Ansari, Mohammed T, Tricco, Andrea C, Loit, Evelin, Weeks, Laura, Doucette, Steve, Skidmore, Becky, Hoch, Jeffrey S, Tsouros, Sophia, Sears, Margaret, Sy, Richmond, Karsh, Jacob, Mani, Suja, Galipeau, James, Yurkiewich, Alexander, Daniel, Raymond, Tsertsvadze, Alexander, Yazdi, Fatemeh
Médium: Artigo
Jazyk:Inglês
Vydáno: United States. Agency for Healthcare Research and Quality 2010
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4781432/
https://ncbi.nlm.nih.gov/pubmed/23126559
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