Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine

AIMS: To examine the allelic variation of three enzymes involved in 6-mercaptopurine/azathioprine (6-MP/AZA) metabolism and evaluate the influence of these polymorphisms on toxicity, haematological parameters and metabolite levels in patients with acute lymphoblastic leukaemia (ALL) or inflammatory...

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Main Authors: Hawwa, Ahmed F, Millership, Jeff S, Collier, Paul S, Vandenbroeck, Koen, McCarthy, Anthony, Dempsey, Sid, Cairns, Carole, Collins, John, Rodgers, Colin, McElnay, James C
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2008
Assuntos:
Pharmacogenetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561120/
https://ncbi.nlm.nih.gov/pubmed/18662289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03248.x
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