Assessment of thiopurine methyltransferase activity in patients prescribed azathioprine or other thiopurine-based drugs.

OBJECTIVES: To examine whether pretreatment determination of thiopurine methyltransferase (TPMT) enzymatic activity (phenotyping) or TPMT genotype, to guide thiopurine therapy in chronic autoimmune disease patients, reduces treatment harms. Other objectives included assessing: preanalytic, analytic,...

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Detalhes bibliográficos
Publicado no:Evid Rep Technol Assess (Full Rep)
Main Authors: Booth, Ronald A, Ansari, Mohammed T, Tricco, Andrea C, Loit, Evelin, Weeks, Laura, Doucette, Steve, Skidmore, Becky, Hoch, Jeffrey S, Tsouros, Sophia, Sears, Margaret, Sy, Richmond, Karsh, Jacob, Mani, Suja, Galipeau, James, Yurkiewich, Alexander, Daniel, Raymond, Tsertsvadze, Alexander, Yazdi, Fatemeh
Formato: Artigo
Idioma:Inglês
Publicado em: United States. Agency for Healthcare Research and Quality 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4781432/
https://ncbi.nlm.nih.gov/pubmed/23126559
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