Safe treatment of thiopurine S-methyltransferase deficient Crohn’s disease patients with azathioprine

Thiopurine S-methyltransferase (TPMT) deficient patients develop life threatening haematotoxicity (for example, pancytopenia) when treated with a standard dose of azathioprine (AZA) and 6-mercaptopurine (6-MP) due to excessive accumulation of cytotoxic metabolites. At present, it is generally recomm...

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Detalhes bibliográficos
Main Authors: Kaskas, B A, Louis, E, Hindorf, U, Schaeffeler, E, Deflandre, J, Graepler, F, Schmiegelow, K, Gregor, M, Zanger, U M, Eichelbaum, M, Schwab, M
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright 2003 by Gut 2003
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1773505/
https://ncbi.nlm.nih.gov/pubmed/12477776
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