Safe treatment of thiopurine S-methyltransferase deficient Crohn’s disease patients with azathioprine

Thiopurine S-methyltransferase (TPMT) deficient patients develop life threatening haematotoxicity (for example, pancytopenia) when treated with a standard dose of azathioprine (AZA) and 6-mercaptopurine (6-MP) due to excessive accumulation of cytotoxic metabolites. At present, it is generally recomm...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Kaskas, B A, Louis, E, Hindorf, U, Schaeffeler, E, Deflandre, J, Graepler, F, Schmiegelow, K, Gregor, M, Zanger, U M, Eichelbaum, M, Schwab, M
Format: Artigo
Langue:Inglês
Publié: Copyright 2003 by Gut 2003
Sujets:
Case Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1773505/
https://ncbi.nlm.nih.gov/pubmed/12477776
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires