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Conserved properties of individual Ca(2+)-binding sites in calmodulin

Calmodulin (CaM) is a Ca(2+)-sensing protein that is highly conserved and ubiquitous in eukaryotes. In humans it is a locus of life-threatening cardiomyopathies. The primary function of CaM is to transduce Ca(2+) concentration into cellular signals by binding to a wide range of target proteins in a...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Halling, D. Brent, Liebeskind, Benjamin J., Hall, Amelia W., Aldrich, Richard W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780646/
https://ncbi.nlm.nih.gov/pubmed/26884197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600385113
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