Coordination to lanthanide ions distorts binding site conformation in calmodulin

The Ca(2+)-sensing protein calmodulin (CaM) is a popular model of biological ion binding since it is both experimentally tractable and essential to survival in all eukaryotic cells. CaM modulates hundreds of target proteins and is sensitive to complex patterns of Ca(2+) exposure, indicating that it...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Edington, Sean C., Gonzalez, Andrea, Middendorf, Thomas R., Halling, D. Brent, Aldrich, Richard W., Baiz, Carlos R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889669/
https://ncbi.nlm.nih.gov/pubmed/29545272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722042115
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