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Coordination to lanthanide ions distorts binding site conformation in calmodulin

The Ca(2+)-sensing protein calmodulin (CaM) is a popular model of biological ion binding since it is both experimentally tractable and essential to survival in all eukaryotic cells. CaM modulates hundreds of target proteins and is sensitive to complex patterns of Ca(2+) exposure, indicating that it...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Edington, Sean C., Gonzalez, Andrea, Middendorf, Thomas R., Halling, D. Brent, Aldrich, Richard W., Baiz, Carlos R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889669/
https://ncbi.nlm.nih.gov/pubmed/29545272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722042115
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