The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function

The innate immune system is strongly implicated in the pathogenesis of Alzheimer’s disease (AD). In contrast, the role of adaptive immunity in AD remains largely unknown. However, numerous clinical trials are testing vaccination strategies for AD, suggesting that T and B cells play a pivotal role in...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Marsh, Samuel E., Abud, Edsel M., Lakatos, Anita, Karimzadeh, Alborz, Yeung, Stephen T., Davtyan, Hayk, Fote, Gianna M., Lau, Lydia, Weinger, Jason G., Lane, Thomas E., Inlay, Matthew A., Poon, Wayne W., Blurton-Jones, Mathew
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780638/
https://ncbi.nlm.nih.gov/pubmed/26884167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525466113
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