The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function

The innate immune system is strongly implicated in the pathogenesis of Alzheimer’s disease (AD). In contrast, the role of adaptive immunity in AD remains largely unknown. However, numerous clinical trials are testing vaccination strategies for AD, suggesting that T and B cells play a pivotal role in...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Marsh, Samuel E., Abud, Edsel M., Lakatos, Anita, Karimzadeh, Alborz, Yeung, Stephen T., Davtyan, Hayk, Fote, Gianna M., Lau, Lydia, Weinger, Jason G., Lane, Thomas E., Inlay, Matthew A., Poon, Wayne W., Blurton-Jones, Mathew
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780638/
https://ncbi.nlm.nih.gov/pubmed/26884167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525466113
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