Activation of the STING-dependent type I interferon response reduces microglial reactivity and neuroinflammation

Brain aging and neurodegeneration are associated with prominent microglial reactivity and activation of innate immune response pathways, commonly referred to as neuroinflammation. One such pathway, the type I interferon response, recognizes viral or mitochondrial DNA in the cytoplasm via activation...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Mathur, Vidhu, Burai, Ritwik, Vest, Ryan T., Bonanno, Liana N., Lehallier, Benoit, Zardeneta, Macy, Mistry, Karishma N., Do, Danny, Marsh, Samuel E., Abud, Edsel M., Blurton-Jones, Mathew, Li, Lingyin, Lashuel, Hilal A., Wyss-Coray, Tony
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5806703/
https://ncbi.nlm.nih.gov/pubmed/29268096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.11.032
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