Naïve human pluripotent cells feature a methylation landscape devoid of blastocyst or germline memory

Human embryonic stem cells (hESCs) typically exhibit “primed” pluripotency, analogous to stem cells derived from the mouse post-implantation epiblast. This has led to a search for growth conditions that support self-renewal of hESCs akin to hypomethylated naïve epiblast cells in human pre-implantati...

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Bibliografske podrobnosti
izdano v:Cell Stem Cell
Main Authors: Pastor, William A., Chen, Di, Liu, Wanlu, Kim, Rachel, Sahakyan, Anna, Lukianchikov, Anastasia, Plath, Kathrin, Jacobsen, Steven E., Clark, Amander T.
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779431/
https://ncbi.nlm.nih.gov/pubmed/26853856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.01.019
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