Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases

Hyper-aldosteronism is associated with myocardial dysfunction including induction of cardiac fibrosis and maladaptive hypertrophy. Mechanisms of these cardiotoxicities are not fully understood. Here we show that mineralocorticoid receptor (MR) activation by aldosterone leads to pathological myocardi...

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Publicat a:Nat Commun
Autors principals: Cannavo, Alessandro, Liccardo, Daniela, Eguchi, Akito, Elliott, Katherine J., Traynham, Christopher J., Ibetti, Jessica, Eguchi, Satoru, Leosco, Dario, Ferrara, Nicola, Rengo, Giuseppe, Koch, Walter J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778065/
https://ncbi.nlm.nih.gov/pubmed/26932512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10877
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